Details of the Drug

General Information of Drug (ID: DMYILBE)

Drug Name
Modafinil
Synonyms Provigil; Modiodal
Indication
Disease Entry ICD 11 Status REF
Narcolepsy 7A20 Approved [1]
Bipolar disorder 6A60 Phase 4 [2]
Brain injury NA07.Z Investigative [3]
Therapeutic Class
Neurology Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 273.4
Topological Polar Surface Area (xlogp) 1.7
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 3
ADMET Property
Absorption
The drug is rapidly absorbed following oral administration [4]
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 2: low solubility and high permeability [5]
Bioavailability
80% of drug becomes completely available to its intended biological destination(s) [6]
Elimination
8% of drug is excreted from urine in the unchanged form [5]
Half-life
The concentration or amount of drug in body reduced by one-half in 23 - 215 hours [7]
Metabolism
The drug is metabolized via the hepatic [4]
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 20.9038 micromolar/kg/day [8]
Vd
The volume of distribution (Vd) of drug is 0.9 L/kg [9]
Chemical Identifiers
Formula
C15H15NO2S
IUPAC Name
2-benzhydrylsulfinylacetamide
Canonical SMILES
C1=CC=C(C=C1)C(C2=CC=CC=C2)S(=O)CC(=O)N
InChI
InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
InChIKey
YFGHCGITMMYXAQ-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
4236
ChEBI ID
CHEBI:77585
CAS Number
68693-11-8
DrugBank ID
DB00745
TTD ID
D07HQC
VARIDT ID
DR00411
INTEDE ID
DR1104
ACDINA ID
D00442

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dopamine transporter (DAT) TTVBI8W SC6A3_HUMAN Modulator [10]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [11]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Narcolepsy
ICD Disease Classification 7A20
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Dopamine transporter (DAT) DTT SLC6A3 1.08E-03 -3.08 -1.99
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 1.76E-01 1.26E-01 8.27E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Modafinil (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Tretinoin DM49DUI Minor Increased metabolism of Modafinil caused by Tretinoin mediated induction of CYP450 enzyme. Acne vulgaris [ED80] [29]
Repaglinide DM5SXUV Moderate Increased metabolism of Modafinil caused by Repaglinide mediated induction of CYP450 enzyme. Acute diabete complication [5A2Y] [30]
Pioglitazone DMKJ485 Minor Increased metabolism of Modafinil caused by Pioglitazone mediated induction of CYP450 enzyme. Acute diabete complication [5A2Y] [29]
Ivosidenib DM8S6T7 Moderate Increased metabolism of Modafinil caused by Ivosidenib mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [31]
Midostaurin DMI6E0R Moderate Increased metabolism of Modafinil caused by Midostaurin mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [32]
Oliceridine DM6MDCF Major Increased metabolism of Modafinil caused by Oliceridine mediated induction of CYP450 enzyme. Acute pain [MG31] [33]
Bepridil DM0RKS4 Minor Increased metabolism of Modafinil caused by Bepridil mediated induction of CYP450 enzyme. Angina pectoris [BA40] [29]
Dronedarone DMA8FS5 Moderate Increased metabolism of Modafinil caused by Dronedarone mediated induction of CYP450 enzyme. Angina pectoris [BA40] [34]
Nifedipine DMSVOZT Moderate Increased metabolism of Modafinil caused by Nifedipine mediated induction of CYP450 enzyme. Angina pectoris [BA40] [35]
Bedaquiline DM3906J Major Increased metabolism of Modafinil caused by Bedaquiline mediated induction of CYP450 enzyme. Antimicrobial drug resistance [MG50-MG52] [36]
Methylphenobarbital DMDSWAG Moderate Increased metabolism of Modafinil caused by Methylphenobarbital mediated induction of CYP450 enzyme. Anxiety disorder [6B00-6B0Z] [31]
Halazepam DMPFWO6 Minor Increased metabolism of Modafinil caused by Halazepam mediated induction of CYP450 enzyme. Anxiety disorder [6B00-6B0Z] [29]
Cilostazol DMZMSCT Moderate Decreased metabolism of Modafinil caused by Cilostazol mediated inhibition of CYP450 enzyme. Arterial occlusive disease [BD40] [37]
Posaconazole DMUL5EW Minor Decreased metabolism of Modafinil caused by Posaconazole mediated inhibition of CYP450 enzyme. Aspergillosis [1F20] [35]
Desipramine DMT2FDC Moderate Decreased metabolism of Modafinil caused by Desipramine mediated inhibition of CYP450 enzyme. Attention deficit hyperactivity disorder [6A05] [35]
Dalfopristin DM4LTKV Minor Decreased metabolism of Modafinil caused by Dalfopristin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [35]
Clarithromycin DM4M1SG Minor Decreased metabolism of Modafinil caused by Clarithromycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [35]
Rabeprazole DMMZXIW Moderate Decreased metabolism of Modafinil caused by Rabeprazole mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [35]
Troleandomycin DMUZNIG Minor Decreased metabolism of Modafinil caused by Troleandomycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [35]
Telithromycin DMZ4P3A Minor Decreased metabolism of Modafinil caused by Telithromycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [35]
Cariprazine DMJYDVK Moderate Increased metabolism of Modafinil caused by Cariprazine mediated induction of CYP450 enzyme. Bipolar disorder [6A60] [38]
Erdafitinib DMI782S Major Increased metabolism of Modafinil caused by Erdafitinib mediated induction of CYP450 enzyme. Bladder cancer [2C94] [39]
Pexidartinib DMS2J0Z Moderate Increased metabolism of Modafinil caused by Pexidartinib mediated induction of CYP450 enzyme. Bone/articular cartilage neoplasm [2F7B] [40]
Ixabepilone DM2OZ3G Minor Increased metabolism of Modafinil caused by Ixabepilone mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [29]
Lapatinib DM3BH1Y Moderate Decreased metabolism of Modafinil caused by Lapatinib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [41]
HKI-272 DM6QOVN Major Increased metabolism of Modafinil caused by HKI-272 mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [35]
LY2835219 DM93VBZ Moderate Increased metabolism of Modafinil caused by LY2835219 mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [42]
Exemestane DM9HPW3 Moderate Increased metabolism of Modafinil caused by Exemestane mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [43]
Esterified estrogens DM9KZDO Minor Increased metabolism of Modafinil caused by Esterified estrogens mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [29]
Tucatinib DMBESUA Moderate Increased metabolism of Modafinil caused by Tucatinib mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [44]
Palbociclib DMD7L94 Moderate Increased metabolism of Modafinil caused by Palbociclib mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [35]
Letrozole DMH07Y3 Minor Increased metabolism of Modafinil caused by Letrozole mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [29]
Quinestrol DMJ6H1Z Minor Increased metabolism of Modafinil caused by Quinestrol mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [29]
Cabazitaxel DMPAZHC Minor Increased metabolism of Modafinil caused by Cabazitaxel mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [29]
Bosutinib DMTI8YE Major Increased metabolism of Modafinil caused by Bosutinib mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [45]
Estradiol DMUNTE3 Minor Increased metabolism of Modafinil caused by Estradiol mediated induction of CYP450 enzyme. Breast cancer [2C60-2C6Y] [29]
Atorvastatin DMF28YC Minor Increased metabolism of Modafinil caused by Atorvastatin mediated induction of CYP450 enzyme. Cardiovascular disease [BA00-BE2Z] [29]
Macitentan DMP79A1 Minor Increased metabolism of Modafinil caused by Macitentan mediated induction of CYP450 enzyme. Cardiovascular disease [BA00-BE2Z] [29]
PF-04449913 DMSB068 Major Increased metabolism of Modafinil caused by PF-04449913 mediated induction of CYP450 enzyme. Chronic myelomonocytic leukaemia [2A40] [46]
Phenylbutazone DMAYL0T Moderate Increased metabolism of Modafinil caused by Phenylbutazone mediated induction of CYP450 enzyme. Chronic pain [MG30] [31]
Dihydrocodeine DMB0FWL Minor Increased metabolism of Modafinil caused by Dihydrocodeine mediated induction of CYP450 enzyme. Chronic pain [MG30] [29]
Anisindione DM2C48U Moderate Decreased metabolism of Modafinil caused by Anisindione mediated inhibition of CYP450 enzyme. Coagulation defect [3B10] [35]
Irinotecan DMP6SC2 Moderate Increased metabolism of Modafinil caused by Irinotecan mediated induction of CYP450 enzyme. Colorectal cancer [2B91] [47]
Drospirenone DM1A9W3 Moderate Increased metabolism of Modafinil caused by Drospirenone mediated induction of CYP450 enzyme. Contraceptive management [QA21] [35]
Levonorgestrel DM1DP7T Moderate Increased metabolism of Modafinil caused by Levonorgestrel mediated induction of CYP450 enzyme. Contraceptive management [QA21] [35]
Ulipristal DMBNI20 Moderate Increased metabolism of Modafinil caused by Ulipristal mediated induction of CYP450 enzyme. Contraceptive management [QA21] [36]
Norgestimate DMYP4XC Moderate Increased metabolism of Modafinil caused by Norgestimate mediated induction of CYP450 enzyme. Contraceptive management [QA21] [48]
Levobupivacaine DM783CH Minor Increased metabolism of Modafinil caused by Levobupivacaine mediated induction of CYP450 enzyme. Corneal disease [9A76-9A78] [49]
Halothane DM80OZ5 Minor Increased metabolism of Modafinil caused by Halothane mediated induction of CYP450 enzyme. Corneal disease [9A76-9A78] [29]
Alfentanil DMVO0UB Minor Increased metabolism of Modafinil caused by Alfentanil mediated induction of CYP450 enzyme. Corneal disease [9A76-9A78] [29]
Mifepristone DMGZQEF Minor Decreased metabolism of Modafinil caused by Mifepristone mediated inhibition of CYP450 enzyme. Cushing syndrome [5A70] [35]
Osilodrostat DMIJC9X Moderate Increased metabolism of Modafinil caused by Osilodrostat mediated induction of CYP450 enzyme. Cushing syndrome [5A70] [50]
Ivacaftor DMZC1HS Minor Decreased metabolism of Modafinil caused by Ivacaftor mediated inhibition of CYP450 enzyme. Cystic fibrosis [CA25] [35]
Rivaroxaban DMQMBZ1 Minor Increased metabolism of Modafinil caused by Rivaroxaban mediated induction of CYP450 enzyme. Deep vein thrombosis [BD71] [29]
Cyclobenzaprine DM1YBRM Minor Increased metabolism of Modafinil caused by Cyclobenzaprine mediated induction of CYP450 enzyme. Depression [6A70-6A7Z] [29]
Vilazodone DM4LECQ Minor Increased metabolism of Modafinil caused by Vilazodone mediated induction of CYP450 enzyme. Depression [6A70-6A7Z] [29]
Nefazodone DM4ZS8M Minor Decreased metabolism of Modafinil caused by Nefazodone mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [35]
Escitalopram DMFK9HG Moderate Decreased metabolism of Modafinil caused by Escitalopram mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [33]
OPC-34712 DMHG57U Minor Increased metabolism of Modafinil caused by OPC-34712 mediated induction of CYP450 enzyme. Depression [6A70-6A7Z] [29]
Clomipramine DMINRKW Moderate Decreased metabolism of Modafinil caused by Clomipramine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [35]
Doxepin DMPI98T Moderate Decreased metabolism of Modafinil caused by Doxepin mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [35]
Esketamine DMVU687 Major Additive hypertensive effects by the combination of Modafinil and Esketamine. Depression [6A70-6A7Z] [35]
[3H]estrone-3-sulphate DMGPF0N Minor Increased metabolism of Modafinil caused by [3H]estrone-3-sulphate mediated induction of CYP450 enzyme. Discovery agent [N.A.] [29]
Oxybutynine DMJPBAX Minor Increased metabolism of Modafinil caused by Oxybutynine mediated induction of CYP450 enzyme. Discovery agent [N.A.] [29]
Oestradiol valerate and dienogest DMZK0FQ Moderate Increased metabolism of Modafinil caused by Oestradiol valerate and dienogest mediated induction of CYP450 enzyme. Endometriosis [GA10] [48]
Diazepam DM08E9O Moderate Decreased metabolism of Modafinil caused by Diazepam mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [35]
Zonisamide DM0DTF7 Minor Increased metabolism of Modafinil caused by Zonisamide mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [29]
Primidone DM0WX6I Moderate Increased metabolism of Modafinil caused by Primidone mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [31]
Felbamate DM1V5ZS Moderate Increased metabolism of Modafinil caused by Felbamate mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [31]
Oxcarbazepine DM5PU6O Moderate Increased metabolism of Modafinil caused by Oxcarbazepine mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [31]
Cenobamate DMGOVHA Moderate Increased metabolism of Modafinil caused by Cenobamate mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [31]
Tiagabine DMKSQG0 Minor Increased metabolism of Modafinil caused by Tiagabine mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [29]
Stiripentol DMMSDOY Moderate Increased metabolism of Modafinil caused by Stiripentol mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [36]
Fosphenytoin DMOX3LB Moderate Decreased metabolism of Modafinil caused by Fosphenytoin mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [35]
Brivaracetam DMSEPK8 Minor Decreased metabolism of Modafinil caused by Brivaracetam mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [36]
Clonazepam DMTO13J Minor Increased metabolism of Modafinil caused by Clonazepam mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [29]
Rufinamide DMWE60C Moderate Increased metabolism of Modafinil caused by Rufinamide mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [31]
Phenobarbital DMXZOCG Moderate Increased metabolism of Modafinil caused by Phenobarbital mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [31]
Eslicarbazepine DMZREFQ Moderate Increased metabolism of Modafinil caused by Eslicarbazepine mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [31]
Praziquantel DMOU1PK Moderate Increased metabolism of Modafinil caused by Praziquantel mediated induction of CYP450 enzyme. Flatworm infection [1F70-1F86] [51]
Bay 80-6946 DMLOS5R Moderate Increased metabolism of Modafinil caused by Bay 80-6946 mediated induction of CYP450 enzyme. Follicular lymphoma [2A80] [52]
Tazemetostat DMWP1BH Major Increased metabolism of Modafinil caused by Tazemetostat mediated induction of CYP450 enzyme. Follicular lymphoma [2A80] [53]
Solifenacin DMG592Q Minor Increased metabolism of Modafinil caused by Solifenacin mediated induction of CYP450 enzyme. Functional bladder disorder [GC50] [29]
Mirabegron DMS1GYT Minor Increased metabolism of Modafinil caused by Mirabegron mediated induction of CYP450 enzyme. Functional bladder disorder [GC50] [54]
Tolterodine DMSHPW8 Minor Increased metabolism of Modafinil caused by Tolterodine mediated induction of CYP450 enzyme. Functional bladder disorder [GC50] [29]
Itraconazole DMCR1MV Minor Decreased metabolism of Modafinil caused by Itraconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [35]
Miconazole DMPMYE8 Minor Decreased metabolism of Modafinil caused by Miconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [35]
Ketoconazole DMPZI3Q Minor Decreased metabolism of Modafinil caused by Ketoconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [35]
Ripretinib DM958QB Moderate Increased metabolism of Modafinil caused by Ripretinib mediated induction of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [35]
Sunitinib DMCBJSR Moderate Increased metabolism of Modafinil caused by Sunitinib mediated induction of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [35]
Avapritinib DMK2GZX Major Increased metabolism of Modafinil caused by Avapritinib mediated induction of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [36]
Colchicine DM2POTE Minor Increased metabolism of Modafinil caused by Colchicine mediated induction of CYP450 enzyme. Gout [FA25] [29]
Sulfinpyrazone DMEV954 Moderate Increased metabolism of Modafinil caused by Sulfinpyrazone mediated induction of CYP450 enzyme. Gout [FA25] [31]
Boceprevir DMBSHMF Minor Decreased metabolism of Modafinil caused by Boceprevir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [35]
PSI-7977 DMLSUWZ Major Accelerated clearance of Modafinil due to the transporter induction by PSI-7977. Hepatitis virus infection [1E50-1E51] [35]
Telaprevir DMMRV29 Minor Decreased metabolism of Modafinil caused by Telaprevir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [35]
Daclatasvir DMSFK9V Major Increased metabolism of Modafinil caused by Daclatasvir mediated induction of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [36]
Isoniazid DM5JVS3 Minor Decreased metabolism of Modafinil caused by Isoniazid mediated inhibition of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [35]
Rifampin DMA8J1G Moderate Increased metabolism of Modafinil caused by Rifampin mediated induction of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [31]
Rifapentine DMCHV4I Moderate Increased metabolism of Modafinil caused by Rifapentine mediated induction of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [31]
Pretomanid DMDYA31 Major Increased metabolism of Modafinil caused by Pretomanid mediated induction of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [55]
MK-1439 DM215WE Major Increased metabolism of Modafinil caused by MK-1439 mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [36]
Fosamprenavir DM4W9B3 Moderate Increased metabolism of Modafinil caused by Fosamprenavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [56]
Fostemsavir DM50ILT Minor Increased metabolism of Modafinil caused by Fostemsavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [57]
Cobicistat DM6L4H2 Moderate Increased metabolism of Modafinil caused by Cobicistat mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [33]
Dolutegravir DMCZGRE Minor Increased metabolism of Modafinil caused by Dolutegravir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [29]
Saquinavir DMG814N Moderate Increased metabolism of Modafinil caused by Saquinavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [56]
Elvitegravir DMG9B1U Moderate Increased metabolism of Modafinil caused by Elvitegravir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [35]
Etravirine DMGV8QU Moderate Increased metabolism of Modafinil caused by Etravirine mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [58]
Lopinavir DMITQS0 Moderate Decreased metabolism of Modafinil caused by Lopinavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [31]
Rilpivirine DMJ0QOW Moderate Increased metabolism of Modafinil caused by Rilpivirine mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [35]
Darunavir DMN3GCH Minor Decreased metabolism of Modafinil caused by Darunavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [35]
Atazanavir DMSYRBX Moderate Increased metabolism of Modafinil caused by Atazanavir mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [56]
Maraviroc DMTL94F Moderate Increased metabolism of Modafinil caused by Maraviroc mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [35]
BMS-201038 DMQTAGO Moderate Decreased clearance of Modafinil due to the transporter inhibition by BMS-201038. Hyper-lipoproteinaemia [5C80] [59]
Levamlodipine DM92S6N Minor Increased metabolism of Modafinil caused by Levamlodipine mediated induction of CYP450 enzyme. Hypertension [BA00-BA04] [29]
Felodipine DMOSW35 Moderate Increased metabolism of Modafinil caused by Felodipine mediated induction of CYP450 enzyme. Hypertension [BA00-BA04] [35]
Conivaptan DM1V329 Minor Decreased metabolism of Modafinil caused by Conivaptan mediated inhibition of CYP450 enzyme. Hypo-osmolality/hyponatraemia [5C72] [35]
Tolvaptan DMIWFRL Moderate Increased metabolism of Modafinil caused by Tolvaptan mediated induction of CYP450 enzyme. Hypo-osmolality/hyponatraemia [5C72] [36]
Berotralstat DMWA2DZ Minor Decreased metabolism of Modafinil caused by Berotralstat mediated inhibition of CYP450 enzyme. Innate/adaptive immunodeficiency [4A00] [35]
Suvorexant DM0E6S3 Minor Decreased metabolism of Modafinil caused by Suvorexant mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [35]
Amobarbital DM0GQ8N Moderate Increased metabolism of Modafinil caused by Amobarbital mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [31]
Ramelteon DM7IW9J Moderate Increased metabolism of Modafinil caused by Ramelteon mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [60]
Triazolam DMETYK5 Moderate Increased metabolism of Modafinil caused by Triazolam mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [31]
Tasimelteon DMLOQ1V Moderate Increased metabolism of Modafinil caused by Tasimelteon mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [61]
ITI-007 DMUQ1DO Major Increased metabolism of Modafinil caused by ITI-007 mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [62]
Quazepam DMY4D87 Minor Increased metabolism of Modafinil caused by Quazepam mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [29]
Estazolam DMZGXUM Minor Increased metabolism of Modafinil caused by Estazolam mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [29]
Naloxegol DML0B41 Minor Increased metabolism of Modafinil caused by Naloxegol mediated induction of CYP450 enzyme. Large intestine motility disorder [DB32] [29]
Pemigatinib DM819JF Major Increased metabolism of Modafinil caused by Pemigatinib mediated induction of CYP450 enzyme. Liver cancer [2C12] [36]
Crizotinib DM4F29C Minor Decreased metabolism of Modafinil caused by Crizotinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [35]
Ceritinib DMB920Z Moderate Increased metabolism of Modafinil caused by Ceritinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [63]
Lurbinectedin DMEFRTZ Major Decreased metabolism of Modafinil caused by Lurbinectedin mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [64]
PF-06463922 DMKM7EW Major Increased metabolism of Modafinil caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [65]
Osimertinib DMRJLAT Moderate Increased metabolism of Modafinil caused by Osimertinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [66]
Pralsetinib DMWU0I2 Moderate Increased metabolism of Modafinil caused by Pralsetinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [67]
Capmatinib DMYCXKL Major Increased metabolism of Modafinil caused by Capmatinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [68]
Selpercatinib DMZR15V Moderate Increased metabolism of Modafinil caused by Selpercatinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [36]
Artemether DM48QOT Moderate Increased metabolism of Modafinil caused by Artemether mediated induction of CYP450 enzyme. Malaria [1F40-1F45] [35]
Proguanil DMBL79I Moderate Decreased metabolism of Modafinil caused by Proguanil mediated inhibition of CYP450 enzyme. Malaria [1F40-1F45] [35]
Halofantrine DMOMK1V Minor Increased metabolism of Modafinil caused by Halofantrine mediated induction of CYP450 enzyme. Malaria [1F40-1F45] [29]
Idelalisib DM602WT Minor Decreased metabolism of Modafinil caused by Idelalisib mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [35]
GDC-0199 DMH0QKA Major Increased metabolism of Modafinil caused by GDC-0199 mediated induction of CYP450 enzyme. Mature B-cell leukaemia [2A82] [69]
IPI-145 DMWA24P Moderate Increased metabolism of Modafinil caused by IPI-145 mediated induction of CYP450 enzyme. Mature B-cell leukaemia [2A82] [70]
Acalabrutinib DM7GCVW Moderate Increased metabolism of Modafinil caused by Acalabrutinib mediated induction of CYP450 enzyme. Mature B-cell lymphoma [2A85] [71]
Ibrutinib DMHZCPO Minor Increased metabolism of Modafinil caused by Ibrutinib mediated induction of CYP450 enzyme. Mature B-cell lymphoma [2A85] [29]
Ponatinib DMYGJQO Minor Increased metabolism of Modafinil caused by Ponatinib mediated induction of CYP450 enzyme. Mature B-cell lymphoma [2A85] [29]
Arry-162 DM1P6FR Moderate Increased metabolism of Modafinil caused by Arry-162 mediated induction of CYP450 enzyme. Melanoma [2C30] [35]
Vemurafenib DM62UG5 Moderate Increased metabolism of Modafinil caused by Vemurafenib mediated induction of CYP450 enzyme. Melanoma [2C30] [72]
Selumetinib DMC7W6R Major Increased metabolism of Modafinil caused by Selumetinib mediated induction of CYP450 enzyme. Melanoma [2C30] [73]
LGX818 DMNQXV8 Major Increased metabolism of Modafinil caused by LGX818 mediated induction of CYP450 enzyme. Melanoma [2C30] [74]
Dabrafenib DMX6OE3 Moderate Increased metabolism of Modafinil caused by Dabrafenib mediated induction of CYP450 enzyme. Melanoma [2C30] [36]
Ethinyl estradiol DMODJ40 Moderate Increased metabolism of Modafinil caused by Ethinyl estradiol mediated induction of CYP450 enzyme. Menopausal disorder [GA30] [48]
Danazol DML8KTN Minor Decreased metabolism of Modafinil caused by Danazol mediated inhibition of CYP450 enzyme. Menstrual cycle bleeding disorder [GA20] [35]
Ubrogepant DM749I3 Moderate Increased metabolism of Modafinil caused by Ubrogepant mediated induction of CYP450 enzyme. Migraine [8A80] [75]
Almogran DM7I64Z Minor Increased metabolism of Modafinil caused by Almogran mediated induction of CYP450 enzyme. Migraine [8A80] [29]
Rimegepant DMHOAUG Major Increased metabolism of Modafinil caused by Rimegepant mediated induction of CYP450 enzyme. Migraine [8A80] [76]
Exjade DMHPRWG Moderate Increased metabolism of Modafinil caused by Exjade mediated induction of CYP450 enzyme. Mineral absorption/transport disorder [5C64] [31]
Flibanserin DM70DTN Moderate Increased metabolism of Modafinil caused by Flibanserin mediated induction of CYP450 enzyme. Mood disorder [6A60-6E23] [77]
Panobinostat DM58WKG Moderate Increased metabolism of Modafinil caused by Panobinostat mediated induction of CYP450 enzyme. Multiple myeloma [2A83] [78]
Siponimod DM2R86O Major Increased metabolism of Modafinil caused by Siponimod mediated induction of CYP450 enzyme. Multiple sclerosis [8A40] [35]
Deflazacort DMV0RNS Major Increased metabolism of Modafinil caused by Deflazacort mediated induction of CYP450 enzyme. Muscular dystrophy [8C70] [36]
Fedratinib DM4ZBK6 Major Increased metabolism of Modafinil caused by Fedratinib mediated induction of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [36]
Nilotinib DM7HXWT Minor Decreased metabolism of Modafinil caused by Nilotinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [35]
Ruxolitinib DM7Q98D Minor Increased metabolism of Modafinil caused by Ruxolitinib mediated induction of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [29]
Busulfan DMXYJ9C Minor Increased metabolism of Modafinil caused by Busulfan mediated induction of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [29]
Rolapitant DM8XP26 Moderate Increased metabolism of Modafinil caused by Rolapitant mediated induction of CYP450 enzyme. Nausea/vomiting [MD90] [36]
Netupitant DMEKAYI Minor Decreased metabolism of Modafinil caused by Netupitant mediated inhibition of CYP450 enzyme. Nausea/vomiting [MD90] [35]
Granisetron DMIUW25 Minor Increased metabolism of Modafinil caused by Granisetron mediated induction of CYP450 enzyme. Nausea/vomiting [MD90] [29]
Ondansetron DMOTQ1I Minor Increased metabolism of Modafinil caused by Ondansetron mediated induction of CYP450 enzyme. Nausea/vomiting [MD90] [29]
Entrectinib DMMPTLH Major Increased metabolism of Modafinil caused by Entrectinib mediated induction of CYP450 enzyme. Non-small cell lung cancer [2C25] [79]
Levomethadyl Acetate DM06HG5 Major Increased metabolism of Modafinil caused by Levomethadyl Acetate mediated induction of CYP450 enzyme. Opioid use disorder [6C43] [80]
S-297995 DM26IH8 Minor Increased metabolism of Modafinil caused by S-297995 mediated induction of CYP450 enzyme. Opioid use disorder [6C43] [29]
Olaparib DM8QB1D Major Increased metabolism of Modafinil caused by Olaparib mediated induction of CYP450 enzyme. Ovarian cancer [2C73] [35]
Rucaparib DM9PVX8 Minor Decreased metabolism of Modafinil caused by Rucaparib mediated inhibition of CYP450 enzyme. Ovarian cancer [2C73] [35]
Buprenorphine DMPRI8G Minor Increased metabolism of Modafinil caused by Buprenorphine mediated induction of CYP450 enzyme. Pain [MG30-MG3Z] [29]
Hydrocodone DMQ2JO5 Major Increased metabolism of Modafinil caused by Hydrocodone mediated induction of CYP450 enzyme. Pain [MG30-MG3Z] [33]
Istradefylline DM20VSK Minor Increased metabolism of Modafinil caused by Istradefylline mediated induction of CYP450 enzyme. Parkinsonism [8A00] [29]
Pimavanserin DMR7IVC Moderate Increased metabolism of Modafinil caused by Pimavanserin mediated induction of CYP450 enzyme. Parkinsonism [8A00] [81]
Abametapir DM2RX0I Moderate Decreased metabolism of Modafinil caused by Abametapir mediated inhibition of CYP450 enzyme. Pediculosis [1G00] [82]
Macimorelin DMQYJIR Moderate Increased metabolism of Modafinil caused by Macimorelin mediated induction of CYP450 enzyme. Pituitary gland disorder [5A60-5A61] [83]
Lefamulin DME6G97 Major Increased metabolism of Modafinil caused by Lefamulin mediated induction of CYP450 enzyme. Pneumonia [CA40] [84]
Ergonovine DM0VEC1 Moderate Increased metabolism of Modafinil caused by Ergonovine mediated induction of CYP450 enzyme. Postpartum haemorrhage [JA43] [35]
Lonafarnib DMGM2Z6 Major Increased metabolism of Modafinil caused by Lonafarnib mediated induction of CYP450 enzyme. Premature ageing appearance [LD2B] [85]
Enzalutamide DMGL19D Moderate Increased metabolism of Modafinil caused by Enzalutamide mediated induction of CYP450 enzyme. Prostate cancer [2C82] [86]
Darolutamide DMV7YFT Moderate Increased metabolism of Modafinil caused by Darolutamide mediated induction of CYP450 enzyme. Prostate cancer [2C82] [87]
Silodosin DMJSBT6 Moderate Increased metabolism of Modafinil caused by Silodosin mediated induction of CYP450 enzyme. Prostate hyperplasia [GA90] [35]
Dutasteride DMQ4TJK Minor Increased metabolism of Modafinil caused by Dutasteride mediated induction of CYP450 enzyme. Prostate hyperplasia [GA90] [29]
Apremilast DMTWS9E Minor Increased metabolism of Modafinil caused by Apremilast mediated induction of CYP450 enzyme. Psoriasis [EA90] [29]
Ambrisentan DMD1QXW Minor Increased metabolism of Modafinil caused by Ambrisentan mediated induction of CYP450 enzyme. Pulmonary hypertension [BB01] [29]
Riociguat DMXBLMP Minor Increased metabolism of Modafinil caused by Riociguat mediated induction of CYP450 enzyme. Pulmonary hypertension [BB01] [29]
Everolimus DM8X2EH Moderate Increased metabolism of Modafinil caused by Everolimus mediated induction of CYP450 enzyme. Renal cell carcinoma [2C90] [35]
Axitinib DMGVH6N Major Increased metabolism of Modafinil caused by Axitinib mediated induction of CYP450 enzyme. Renal cell carcinoma [2C90] [88]
Temsirolimus DMS104F Minor Increased metabolism of Modafinil caused by Temsirolimus mediated induction of CYP450 enzyme. Renal cell carcinoma [2C90] [29]
Upadacitinib DM32B5U Moderate Increased metabolism of Modafinil caused by Upadacitinib mediated induction of CYP450 enzyme. Rheumatoid arthritis [FA20] [89]
Tofacitinib DMBS370 Minor Increased metabolism of Modafinil caused by Tofacitinib mediated induction of CYP450 enzyme. Rheumatoid arthritis [FA20] [29]
Dexamethasone DMMWZET Moderate Increased metabolism of Modafinil caused by Dexamethasone mediated induction of CYP450 enzyme. Rheumatoid arthritis [FA20] [31]
Quetiapine DM1N62C Minor Increased metabolism of Modafinil caused by Quetiapine mediated induction of CYP450 enzyme. Schizophrenia [6A20] [29]
Aripiprazole DM3NUMH Minor Increased metabolism of Modafinil caused by Aripiprazole mediated induction of CYP450 enzyme. Schizophrenia [6A20] [29]
Pimozide DMW83TP Minor Increased metabolism of Modafinil caused by Pimozide mediated induction of CYP450 enzyme. Schizophrenia [6A20] [29]
Fentanyl DM8WAHT Major Increased metabolism of Modafinil caused by Fentanyl mediated induction of CYP450 enzyme. Sensation disturbance [MB40] [33]
Avanafil DM75CXN Minor Increased metabolism of Modafinil caused by Avanafil mediated induction of CYP450 enzyme. Sexual dysfunction [HA00-HA01] [29]
Tadalafil DMJZHT1 Minor Increased metabolism of Modafinil caused by Tadalafil mediated induction of CYP450 enzyme. Sexual dysfunction [HA00-HA01] [29]
Vardenafil DMTBGW8 Minor Increased metabolism of Modafinil caused by Vardenafil mediated induction of CYP450 enzyme. Sexual dysfunction [HA00-HA01] [29]
Voxelotor DMCS6M5 Major Increased metabolism of Modafinil caused by Voxelotor mediated induction of CYP450 enzyme. Sickle-cell disorder [3A51] [90]
LDE225 DMM9F25 Major Increased metabolism of Modafinil caused by LDE225 mediated induction of CYP450 enzyme. Skin cancer [2C30-2C37] [91]
Telotristat ethyl DMDIYFZ Moderate Increased metabolism of Modafinil caused by Telotristat ethyl mediated induction of CYP450 enzyme. Small intestine developmental anomaly [DA90] [36]
Larotrectinib DM26CQR Moderate Increased metabolism of Modafinil caused by Larotrectinib mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [35]
Methylprednisolone DM4BDON Minor Increased metabolism of Modafinil caused by Methylprednisolone mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [29]
Ifosfamide DMCT3I8 Minor Increased metabolism of Modafinil caused by Ifosfamide mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [92]
Docetaxel DMDI269 Minor Increased metabolism of Modafinil caused by Docetaxel mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [29]
Trabectedin DMG3Y89 Moderate Increased metabolism of Modafinil caused by Trabectedin mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [36]
LEE011 DMMX75K Moderate Increased metabolism of Modafinil caused by LEE011 mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [35]
Etoposide DMNH3PG Minor Increased metabolism of Modafinil caused by Etoposide mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [29]
Prednisolone DMQ8FR2 Minor Increased metabolism of Modafinil caused by Prednisolone mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [29]
Taxol DMUOT9V Minor Increased metabolism of Modafinil caused by Taxol mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [29]
Doxorubicin DMVP5YE Minor Increased metabolism of Modafinil caused by Doxorubicin mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [29]
Fostamatinib DM6AUHV Moderate Increased metabolism of Modafinil caused by Fostamatinib mediated induction of CYP450 enzyme. Thrombocytopenia [3B64] [93]
Apixaban DM89JLN Minor Increased metabolism of Modafinil caused by Apixaban mediated induction of CYP450 enzyme. Thrombosis [DB61-GB90] [29]
Brilinta DMBR01X Moderate Increased metabolism of Modafinil caused by Brilinta mediated induction of CYP450 enzyme. Thrombosis [DB61-GB90] [33]
Clopidogrel DMOL54H Moderate Decreased metabolism of Modafinil caused by Clopidogrel mediated inhibition of CYP450 enzyme. Thrombosis [DB61-GB90] [94]
Sirolimus DMGW1ID Moderate Increased metabolism of Modafinil caused by Sirolimus mediated induction of CYP450 enzyme. Transplant rejection [NE84] [35]
Tacrolimus DMZ7XNQ Moderate Increased metabolism of Modafinil caused by Tacrolimus mediated induction of CYP450 enzyme. Transplant rejection [NE84] [35]
Saxagliptin DMGXENV Minor Increased metabolism of Modafinil caused by Saxagliptin mediated induction of CYP450 enzyme. Type 2 diabetes mellitus [5A11] [29]
Linagliptin DMWFJTR Moderate Increased metabolism of Modafinil caused by Linagliptin mediated induction of CYP450 enzyme. Type 2 diabetes mellitus [5A11] [95]
Elagolix DMB2C0E Moderate Increased metabolism of Modafinil caused by Elagolix mediated induction of CYP450 enzyme. Uterine fibroid [2E86] [96]
Betrixaban DM2C4RF Moderate Accelerated clearance of Modafinil due to the transporter induction by Betrixaban. Venous thromboembolism [BD72] [97]
⏷ Show the Full List of 227 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Mannitol E00103 6251 Diluent; Flavoring agent; Lyophilization aid; Plasticizing agent; Tonicity agent
Sodium lauryl sulfate E00464 3423265 Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Sodium stearyl fumarate E00545 23665634 lubricant
Beta-D-lactose E00099 6134 Diluent; Dry powder inhaler carrier; Lyophilization aid
Calcium hydrogenphosphate E00294 24441 Diluent
Carmellose sodium E00625 Not Available Disintegrant
Crospovidone E00626 Not Available Disintegrant
Lactose monohydrate E00393 104938 Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate E00208 11177 lubricant
Povidone E00667 Not Available Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Silicon dioxide E00670 Not Available Anticaking agent; Opacifying agent; Viscosity-controlling agent
Talc E00520 16211421 Anticaking agent; Diluent; Glidant; lubricant
Vinylpyrrolidone E00668 Not Available Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
⏷ Show the Full List of 13 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Modafinil 100 mg tablet 100 mg Oral Tablet Oral
Modafinil 200 mg tablet 200 mg Oral Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 ClinicalTrials.gov (NCT01965925) Targeting Circadian and Cognitive Dysfunction in Bipolar Disorder With Modafinil. U.S. National Institutes of Health.
3 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
4 FDA approval: ado-trastuzumab emtansine for the treatment of patients with HER2-positive metastatic breast cancer. Clin Cancer Res. 2014 Sep 1;20(17):4436-41.
5 BDDCS applied to over 900 drugs
6 Critical Evaluation of Human Oral Bioavailability for Pharmaceutical Drugs by Using Various Cheminformatics Approaches
7 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
8 Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
9 An FDA phase I clinical trial of quinacrine sterilization (QS). Int J Gynaecol Obstet. 2003 Oct;83 Suppl 2:S45-9.
10 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
11 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
12 Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. Cancer. 2007 Mar 1;109(5):957-65.
13 Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998 Jun;28(6):539-47.
14 Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.
15 Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone. Drug Metab Dispos. 2013 Feb;41(2):263-9.
16 Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772.
17 Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates. Br J Pharmacol. 2012 Apr;165(8):2787-98.
18 Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos. 2007 Apr;28(3):151-6.
19 The metabolism of zidovudine by human liver microsomes in vitro: formation of 3'-amino-3'-deoxythymidine. Biochem Pharmacol. 1994 Jul 19;48(2):267-76.
20 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
21 Differential involvement of the norepinephrine, serotonin and dopamine reuptake transporter proteins in cocaine-induced taste aversion. Pharmacol Biochem Behav. 2009 Jul;93(1):75-81.
22 Dasotraline for the Treatment of Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind, Placebo-Controlled, Proof-of-Concept Trial in Adults. Neuropsychopharmacology. 2015 Nov;40(12):2745-52.
23 Imaging the effects of methylphenidate on brain dopamine: new model on its therapeutic actions for attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005 Jun 1;57(11):1410-5.
24 Interaction of the anorectic medication, phendimetrazine, and its metabolites with monoamine transporters in rat brain. Eur J Pharmacol. 2002 Jun 28;447(1):51-7.
25 Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. J Med Chem. 2007 May 31;50(11):2718-31.
26 Rapid detection of Parkinson's disease by SPECT with altropane: a selective ligand for dopamine transporters. Synapse. 1998 Jun;29(2):128-41.
27 Anti-obesity drugs. Expert Opin Pharmacother. 2008 Jun;9(8):1339-50.
28 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 927).
29 Doherty MM, Charman WN "The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism?" Clin Pharmacokinet 41 (2002): 235-53. [PMID: 11978143]
30 Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT "CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide." Br J Clin Pharmacol 56 (2003): 305-14. [PMID: 12919179]
31 Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
32 Dutreix C, Munarini F, Lorenzo S, Roesel J, Wang Y "Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers." Cancer Chemother Pharmacol 72 (2013): 1223-34. [PMID: 24085261]
33 Canadian Pharmacists Association.
34 Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
35 Cerner Multum, Inc. "Australian Product Information.".
36 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
37 Hedaya MA, El-Afify DR, El-Maghraby GM "The effect of ciprofloxacin and clarithromycin on sildenafil oral bioavailability in human volunteers." Biopharm Drug Dispos 27 (2006): 103-10. [PMID: 16372380]
38 Product Information. Vraylar (cariprazine). Actavis Pharma, Inc., Parsippany, NJ.
39 Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
40 Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
41 Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
42 Product Information. Verzenio (abemaciclib). Lilly, Eli and Company, Indianapolis, IN.
43 Product Information. Aromasin (exemestane) Pharmacia & Upjohn, Kalamazoo, MI.
44 Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
45 Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
46 Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
47 Crews KR, Stewart CF, Jones-Wallace D, et al "Altered irinotecan pharmacokinetics in pediatric high-grade glioma patients receiving enzyme-inducing anticonvulsant therapy." Clin Cancer Res 8 (2002): 2202-9. [PMID: 12114421]
48 Faculty of Sexual & Reproductive Healthcare "FSRH Clinical Guidance: Drug Interactions with Hormonal Contraception.".
49 Product Information. Chirocaine (levobupivacaine) Organon, West Orange, NJ.
50 Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
51 Bittencourt PR, Gracia CM, Martins R, et al "Phenytoin and carbamazepine decrease oral bioavailability of praziquantel." Neurology 42 (1992): 492-6. [PMID: 1549207]
52 Product Information. Aliqopa (copanlisib). Bayer Pharmaceutical Inc, West Haven, CT.
53 Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
54 Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
55 Product Information. Pretomanid (pretomanid). The Global Alliance for TB Drug Development, New York, NY.
56 Barry M, Gibbons S, Back D, Mulcahy F "Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations." Clin Pharmacokinet 32 (1997): 194-209. [PMID: 9084959]
57 Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
58 Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
59 Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
60 Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL.
61 Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
62 Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
63 Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
64 Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
65 Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
66 Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
67 Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
68 Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
69 Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
70 Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
71 Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
72 Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
73 Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
74 Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
75 Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
76 Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
77 Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
78 Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
79 Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
80 Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
81 Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
82 Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
83 Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
84 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
85 Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
86 Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
87 Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
88 Pithavala YK, Tortorici M, Toh M, et al "Effect of rifampin on the pharmacokinetics of axitinib (AG-013736) in Japanese and Caucasian healthy volunteers." Cancer Chemother Pharmacol 65 (2010): 563-70. [PMID: 19603168]
89 Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
90 Product Information. Oxbryta (voxelotor). Global Blood Therapeutics, Inc., South San Francisco, CA.
91 Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
92 Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
93 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
94 Collet JP, Hulot JS, Pena A, et al. "Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study." Lancet 373 (2009): 309-17. [PMID: 19108880]
95 Product Information. Tradjenta (linagliptin). Boehringer Ingelheim, Ridgefield, CT.
96 Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
97 Gelosa P, Castiglioni L, Tenconi M, et.al "Pharmacokinetic drug interactions of the non-vitamin K antagonist oral anticoagulants (NOACs)" Pharmacol Res 135 (2018): 60-79. [PMID: 30040996]